Susan Sweeney, MD, University of California at San Diego

"Activation of Type I IFN Gene Expression: Role of IKK-Related Kinases and Interferon Regulatory Factors in SLE"

2006 Novel Pilot Projects Program

The Stephen and Catherine Pida Memorial Research Award - The grant was made possible by funds contributed through a trust created in memory of Stephen and Catherine Pida and supported by the Ortleb Family.

Medicines which target selected parts of the immune system are being developed for lupus in the hopes that they will be more effective and might have fewer side effects. Recent studies suggest a role for the small immune protein, interferon in lupus. Chemical signals inside immune cells may cause IFN to be made. Understanding the mechanics that lead to increased IFN production by immune cells might lead to identification of novel treatments for SLE.