Stem Cells and Lupus Research
The LFA believes expanding stem cell research will accelerate the pace of discovery on the potential therapeutic benefits of stem cells and help basic and clinical researchers learn how stem cells can be used to develop life-saving treatments.
About Stem Cells
Stem cells possess the potential to develop into many different types of cells in the body. They serve as a repair system for the body. Mesenchymal stem cells are found in mature tissues that have already developed. The body uses these cells to replace other cells that die off throughout the normal course of life. As they are not from fetal tissue, these stem cells do not have the same ethical concerns or restrictions that embryonic stem cells do. Current research in lupus focuses on mesenchymal stem cells.
About Mesenchymal Stem Cells
Mesenchymal stem cells (MSC) are derived from bone marrow, umbilical cords or other tissues and are anti-inflammatory. These anti-inflammatory cells have unique properties that make them attractive as therapy for autoimmune diseases. Unlike with other stem cells, MSCs lack the properties that enable the immune system to detect them as being foreign. Therefore:
- Donors and recipients do not have to match for treatment to be successful, reducing the risk of rejection.
- Recipients do not need to ablate (remove) their cells with chemotherapy, reducing their risk of infection.
MSCs have been studied in inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and scleroderma. In these studies, MSC treatment has been found to be effective and only minimal side effects reported.
Mesenchymal Stem Cells in Lupus
Pioneering researchers from China have studied MSC treatment in over 200 people with lupus who had been unresponsive to standard lupus therapies. Preliminary results show that:
- As many as 75% (three out of every four) study participants benefited from treatment, a much higher response rate than current treatments for lupus.
- Disease activity in the participants was greatly reduced for as long as 24 months after treatment.
- Adverse reactions were rare, and there were no severe reactions to treatment.
While the findings are groundbreaking, there was no control group in these early studies. This means that every participant received the stem cell treatment plus standard lupus therapies. A controlled trial is necessary to ensure that individuals who receive the MSC therapy plus standard lupus therapies do indeed respond better than closely matched participants who only receive standard therapy.
Audio: Mesenchymal Stem Cells For Treating Lupus
Listen to a conversation with Dr. Gary Gilkeson, Professor of Medicine/Microbiology and Immunology at the Medical University of South Carolina in Charleston. Dr. Gilkeson provides an update on clinical trial that is underway testing whether stem cells can help people with treatment-resistant lupus.
The LFA thus far has awarded 11 grants to advance basic and clinical adult stem cell research as a treatment for lupus. Learn more about all the investigators we have funded for stem cell research.