Richard Burt, MD, Northwestern University School of Medicine

“Hematopoietic Stem Cell Transplantation Induces Remission in Lupus”

2011 Adult Stem Cell Grant Award

This grant award is made possible through support of the LFA, Illinois Chapter

Compared to conventional drug treatment, transplantation of autologous (one’s own) hematopoietic stem cells can result in long-term remission of disease. Dr. Burt pioneered the use of hematopoietic stem cells to treat autoimmune diseases and performed America's first autologous hematopoietic stem cell transplants for numerous autoimmune diseases, including lupus. Under Dr. Burt's direction, Northwestern University’s Center for Immunotherapy has performed more hematopoietic stem cell transplants for autoimmune and immune-mediated diseases than any other center in the world. Dr. Burt has recently reported that 14 of 15 patients in whom he performed a stem cell transplant are free of lupus disease (some for up to eight years after transplantation). Dr. Burt is currently studying changes to the immune system that occur after patients receive stem cell transplantation in order to understand how the remission of lupus takes place.