Mae Thamer, PhD, Medical Technology & Practice Patterns Institute

"Relationship Between Prednisone, Lupus Activity and Organ Failure"

2006 Novel Pilot Projects Program

The mainstay of treatment for lupus is corticosteroids, although they have serious side effects including fractures, coronary artery disease, cataracts, kidney failure, and other types of organ damage. Since both the treatment for lupus and the lupus disease itself are associated with organ damage, it has been difficult to isolate the role of the corticosteroids using traditional statistical techniques. This exploratory study proposes to use innovative analysis techniques to find the causal relationship between corticosteroid therapy and organ damage among lupus patients. This research will provide a basis for improving current treatment and potentially highlight the need to develop new steroid-sparing therapies.