Jean M. Van Seventer, VMD, Boston University School of Public Health

"Modeling the Effects of Type 1 IFN Blockade Therapy During Various Stages of SLE"
Year-Two Funding

2008 Mid-to-Late Stage Translational Lupus Research Grant Award

This grant award is made possible through support of the Wallace H. Coulter Foundation in memory of Michael Jon Barlin

Systemic Lupus Erythematosus (SLE) is an inflammatory autoimmune disease. Type I interferon is a blood factor that is increased in many SLE patients, and that may function to worsen some aspects of the disease while improving others. This study uses mouse models of lupus to determine how inhibiting type l IFN during stages of SLE may make the disease better or worse. It particularly focuses on how blocking type I IFN will affect lupus kidney disease and associated heart disease. The results will directly contribute to the development of safe and efficacious SLE therapies.