James C. Oates, MD, Medical University of South Carolina

"Biomarkers of Reactive Nitrogen and Oxygen Stress as Risk Factors for Cardiovascular Disease in African Americans with Lupus"

2005-2008 Lupus Related Cardiovascular Research Grant Award

Heart attacks and strokes occur more frequently in lupus patients than in the general population. Predicting who will develop "hardening of the arteries" that leads to these events has been a challenge to researchers and practicing rheumatologists, who need to identify those patients who will require medical therapy to prevent atherosclerosis. This proposed project will look at novel markers in the blood of lupus patients and may predict who needs more aggressive medical therapy to prevent heart attacks and strokes. The researchers will use traditional statistics and artificial intelligence to help develop a model that predicts atherosclerosis in lupus.