David S. Pisetsky, MD, PhD, Duke University

"Microparticles in the Pathogenesis of SLE"

2007 Novel Pilot Projects Program

The goal of these investigations is to elucidate the role of MPs in the pathogenesis of systemic lupus erythematosus (SLE). MPs are small membrane-bound vesicles that are released from activated or dying cells and display pro-inflammatory and pro-thrombotic activities. To elucidate these activities in the context of SLE, this grant will address the following aims; I) To analyze the expression of MPs of lymphoid and endothelial origin in the blood of patients with SLE; 2) To characterize the expression of nuclear self antigens in MPs; and 3) To elucidate the mechanism of microparticle release during apoptotic cell death.