Barbara Segal, MD, University of Minnesota

"Fatigue and Oxidative Stress in SLE"

2006 Novel Pilot Projects Program

Persistent, abnormal fatigue is common in people with SLE, but the causes of this fatigue are not well understood. The goal of this study is to determine if dysregulation of genes may be linked to abnormal fatigue in lupus patients. The researchers will compare the activity of genes in the blood cells of patients who have fatigue to the gene activity of those who do not to gather information regarding the possible causes of chronic fatigue. They believe that this research will lead to new insights into the cause of fatigue in persons with SLE and novel therapies to improve the quality of life of patients with autoimmune disease. The genes the researchers are most interested in are those controlling energy pathways and affecting levels of oxidative stress (a mechanism linked to fatigue).